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The Vaccine Race: Science, Politics, and the Human Costs of Defeating Disease
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Review
Shortlisted for the Wellcome Book Prize“Riveting . . . [The Vaccine Race] invites comparison with Rebecca Skloot's 2007 The Immortal Life of Henrietta Lacks.”—Nature “Rich in scientific anecdotes, historical detail and quirky characters. . . She conveys the era’s no-holds-barred approach to science, as well as the altruism of individual scientists and doctors at a time when no one had yet thought of patenting a gene or a living cell… her chapter on the stirrings of entrepreneurship among biologists and universities is an enlightening primer on the birth of the biotech industry.” --Washington Post“Meticulously researched and carefully crafted . . . The Vaccine Race, is an enlightening telling of the development of vaccines in the mid-20th century. . . . an intelligent and entertaining tome . . . [and] a comprehensive portrait of the many issues faced in the race to develop vaccines.” —Science “A riveting tale of scientific infighting, clashing personalities, sketchy ethics, and the transformation of cell biology from a sleepy scientific backwater to a high-stakes arena where vast fortunes are made.” —The Wall Street Journal"Meredith Wadman’s fine, new book details the struggle to develop a rubella vaccine—a tale of revolutionary science on the one hand; gloves-off combat on the other. And it confronts a host of hot-button issues, all beautifully explained..reads like a good detective novel." -David Oshinsky, FASEB Journal “Wadman’s research is extensive, and her book is packed with anecdotes and details of the science, the times, and the people.” —The Boston Globe “The Vaccine Race is an important read—for scientists, politicians, physicians, parents and everyone interested in how the world of medical research works. . . . A very compelling read.” —The Huffington Post “This is a story about the war against disease--a war without end--and the development of enormously important vaccines, but in telling that story, in showing how science works, Meredith Wadman reveals much more. Like all wars, that story includes heroism, risk-taking, persistence, and fighting against the odds, and, like all wars, that story also includes politics, obtuseness, bureaucracy, and fights over money. It's very well-written and does not oversimplify yet explains clearly even the purely scientific parts of the story. In short, I loved this book.” —John M. Barry, New York Times bestselling author of The Great Influenza “Meredith Wadman rolls up her sleeves and takes an uncompromising look at the sometimes unethical, often crude, and always rough-and-tumble world of one of the greatest success stories in public health: vaccines. What she finds will no doubt surprise you.” —Paul A. Offit, MD, author of Pandora's Lab: Seven Stories of Science Gone Wrong and Autism’s False Prophets “A gripping story with strong resonance in the age of Zika and Ebola--and a powerful reminder of the ways in which researchers approached the ethics of medical testing only fifty years ago.” —Henry T. Greely, Director of Stanford's Center for Law and the Biosciences and author of The End of Sex “The fascinating story of the scientific battle over--among other important matters--whether human vaccines should be grown in human or animal cells. The hero of this story is Leonard Hayflick, who favored human cells. Fortunately for all of us, he won out.” —Stanley M. Gartler, Prof. Emeritus, Medical Genetics, University of Washington “An exemplary piece of medical journalism.” —Publisher's Weekly (starred review) “An important story well told, featuring the drama and characters needed to make this a candidate for film adaptation.” —Kirkus Reviews “It is a story of human tragedy and greatness, of curiosity and ambition, of turf battles and ethical lapses, and of what we would call today ‘fake news’ and ‘alternative facts’ about the use of cells from an aborted fetus.” —Dallas Morning News
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About the Author
Meredith Wadman has covered biomedical research politics from Washington for twenty years. She is a reporter at Science and has written for Nature, Fortune, the New York Times, and the Wall Street Journal. A graduate of Stanford and Columbia, she began medical school at the University of British Columbia and completed her medical degree as a Rhodes scholar at the University of Oxford.
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Product details
Hardcover: 448 pages
Publisher: Viking; 1 edition (February 7, 2017)
Language: English
ISBN-10: 0525427538
ISBN-13: 978-0525427537
Product Dimensions:
6.3 x 1.5 x 9.4 inches
Shipping Weight: 1.6 pounds (View shipping rates and policies)
Average Customer Review:
4.4 out of 5 stars
26 customer reviews
Amazon Best Sellers Rank:
#642,256 in Books (See Top 100 in Books)
Writers are ever attracted to the development of modern medicine and biochemistry. At the top of my list is the book "Cancer: the Emperor of all Maladies". Next could be "Science Fictions" and the life of Robert Gallo. Then might be the biography of Paul Berg at Stanford, and gene recombination. Now we have "The Vaccine Race", by Meredith Wadman. These tombs tend to present a challenge to the reader to accommodate the obscure language of Biochemistry. It is a relief that Wadman reads easily. We can accept the ability of viruses to grow in human fetal cells as a simple fact.The life of a research scientist is a thread that runs through these books. After decades of research to the benefit of mankind, something happens to principle investigators. They become autocratic and difficult to work with. Worse, they break the law and the ethics of their profession. Their careers go up in smoke. The strain of cutting edge research and bureaucratic interference is too much to bear. We are humble before the limits of human ambition and endurance.Wadman tells a good story, about the competition between pandemics and vaccines. It takes a few chapters to set her pace and then she takes off. If some chapters are too detailed, we can get the story from the first sentence in each paragraph.
A well written history of the development of several of the key vaccines, staring in the 1950's and running all the way to the 1990's. Vaccines are one of the most important medical breakthroughs (along with penicillin) of the 20th century responsible for savings hundreds of millions of lives and eradicating some of the most horrible diseases of our time. Yet, we still have doubters and still occasional flare ups when people stop vaccinating! Ms. Wadman weaves together the science (it is not linear, doesn't happen without setbacks and often corner cutting!), politics, legal and ethical issues using several larger than life personalities to do so. Provides a great base for understanding some of the key battles that exist to this day.
I'm a retired bioscientist and can remember well the events described by Meredith Wadmax, many of which were known at the time only within the biomedical research community. She effectively put together the history of how arcane research and contentious, but obscure, power struggles among scientists and funding agencies eventually gave rise to the biotechnology revolution, leading to the emergence of an economically important and beneficial industry.
As a scientist and recipient of the human diploid rabies vaccine I thought I would enjoy this book - I did not. It is annoyingly repetitive (to the point where I thought my kindle has a flash back). The author "speaks" with a variety of "voices" - sometimes she uses scientific terms with descriptions and definitions, sometimes she uses over the top adjectives to describe scientists, events, or particular patients, and sometimes she makes novice mistakes as "Plasma is another word for blood serum." Mistakes like that (made by a physician) make one wonder about the veracity of her other scientific descriptions. It is unclear why she insists on using the word "womb" when describing the uterus, unless she believes it has more "emotional" connotation. One could expose the political and competitive issues in the vaccine race without bias. She did not do so. She frequently claims the moral high ground, apparently unaware that our current ability to enlarge our moral circle is a direct result of the fact that in the US (for the most part) our basic needs have been met, we do not suffer from mass epidemics that kill and paralyze, or maim or citizens, and we have disposable time and income. When read as a made for TV novel, rather than scientific history, it is an average, slightly cumbersome read. It could have been a great well written story - it was not
While I don't agree with some of the conclusions the author reached I found the discussion of vaccines, its production and difficulties described to be very enlightening.
When I started this book I knew nothing about immunology. I'm not even a scientist. But from the beginning, I was hooked. There were heroes and villains, drama, a captivating story, and lots of fascinating information. Highly recommended.
The Vaccine Race gets five stars because it's a handicap race --- ie given that it's a book about boring science, it's at least four stars, so it gets five stars from me. It's about Leonard Hayflick and his cultured animal cells. See? Doesn't that leave you cold? It's so arcane and esoteric, you never heard of him, and have only a hazy idea what's up with "cultured animal cells", although since that book came out about Henrietta Lacks and her HeLa cells, we now have quite a few people who have more than a hazy idea of what that's all about, which is good. I'm from Philadelphia and went to Penn and even knew a little bit about the Wistar INstitute at 36th and Pine, so I'm a good judge of whether Ms Wadman did a good job here of giving the flavor of the times and the scientific backdrop for what these guys were doing. She did a fine job of reporting, and it's well written and pretty interesting. I hope a lot of people read The Vaccine Race because one way or another you'll all get to know a lot more about vaccines like MMR ; and vaccines in general; all of which is important. Hell, it's CRUCIAL! Everybody should have some idea of the PROCESS involved. Read it.
Slow going and a bit repetitive
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Mei 26, 2017
desideriahiramcornelieoliver
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